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It was the discovery of melatonin synthesis in endocrine body organs, specifically the pineal gland, neural structures, as well as immunocompetent cells such as T lymphocytes, NK cells, as well as mast cells that activated the brand-new methods to the unifield signal policy of homeostasis, which, at the turn of the 21st century, lead to the creation of a new indispensable biomedical technique - neuroimmunoendocrinology.
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