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Melatonin has been revealed to possess anti-inflammatory effects, among a variety of activities. Melatonin lowers tissue damage throughout inflammatory responses by a variety of methods. Thus melatonin, by virtue of its capability to straight scavenge hazardous free radicals, lowers macromolecular damages in all organs. The totally free radicals and reactive oxygen and nitrogen species known to be fed on by melatonin include the extremely toxic hydroxyl radical, peroxynitrite anion, as well as hypochlorous acid, among others. These agents all add to the inflammatory feedback and also associated tissue damage. In addition, melatonin has other ways to decrease the damage resulting from inflammation.
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