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It was the exploration of melatonin synthesis in endocrine organs, specifically the pineal gland, neural structures, and immunocompetent cells such as T lymphocytes, NK cells, and mast cells that triggered the new methods to the unifield signal regulation of homeostasis, which, at the turn of the 21st century, bring about the production of a new indispensable biomedical technique - neuroimmunoendocrinology.
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