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It was the exploration of melatonin synthesis in endocrine body organs, specifically the pineal gland, neural structures, and immunocompetent cells such as T lymphocytes, NK cells, and mast cells that caused the brand-new techniques to the unifield signal law of homeostasis, which, at the turn of the 21st century, lead to the creation of a new important biomedical discipline - neuroimmunoendocrinology.
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