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It was the exploration of melatonin synthesis in endocrine organs, particularly the pineal gland, neural structures, as well as immunocompetent cells such as T lymphocytes, NK cells, and mast cells that caused the brand-new approaches to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, cause the production of a new essential biomedical technique - neuroimmunoendocrinology.
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