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It was the exploration of melatonin synthesis in endocrine body organs, specifically the pineal gland, neural frameworks, and immunocompetent cells such as T lymphocytes, NK cells, and also mast cells that caused the brand-new methods to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, bring about the production of a brand-new integral biomedical technique - neuroimmunoendocrinology.
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