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It was the exploration of melatonin synthesis in endocrine organs, particularly the pineal gland, neural frameworks, and also immunocompetent cells such as T lymphocytes, NK cells, as well as mast cells that set off the new approaches to the unifield signal law of homeostasis, which, at the turn of the 21st century, lead to the development of a new important biomedical technique - neuroimmunoendocrinology.
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