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It was the discovery of melatonin synthesis in endocrine organs, specifically the pineal gland, neural frameworks, and immunocompetent cells such as T lymphocytes, NK cells, as well as mast cells that set off the new strategies to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, lead to the development of a new important biomedical discipline - neuroimmunoendocrinology.
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